Liver Cirrhosis

Liver cirrhosis is an abnormal liver condition in which there is irreversible scarring of the liver. The main causes are sustained excessive alcohol consumption, viral hepatitis B and C, and fatty liver disease – however, there are many possible causes.

People with liver cirrhosis may develop jaundice (yellowing of the skin, eyes and tongue), itching and extreme tiredness.

For liver cirrhosis to develop long-term, continuous damage to the liver needs to occur. When healthy liver tissue is destroyed and replaced by scar tissue the condition becomes serious, as it can start blocking the flow of blood through the liver. Liver cirrhosis is a progressive disease, developing slowly over many years, until eventually it can stop liver function (liver failure). The liver carries out several essential functions, including the detoxification of harmful substances in the body. It also purifies the blood and manufactures vital nutrients.

If liver cirrhosis is mild the liver can make repairs and continue functioning properly. If the liver cirrhosis is advanced and more and more scar tissue forms in the liver, the damage is irreparable. The liver tissue is replaced by fibrous scar tissue as well as regenerative nodules (lumps that appear as a consequence of a process in which damaged tissue is regenerated).

liver cirrhosis

Causes of Liver Cirrhosis

Common causes of liver cirrhosis are long-term alcohol abuse, hepatitis B and C infection, and fatty liver disease. Of those, hepatitis B and C together are said to be the leading cause of liver cirrhosis (WHO).

Over Consumption of Alcohol
Excessive alcohol consumption is when a man drinks more than 21 units and a woman drinks more than 14 units per week.

Toxins, including alcohol, are broken down by the liver. However, if the amount of alcohol is too high the liver will be overworked and liver cells can eventually become damaged.

Heavy, regular, long-term drinkers are much more likely to develop liver cirrhosis, compared to other healthy people. It is a myth that only alcoholics are at risk – regular and heavy social drinking is also linked to a higher probability of developing liver cirrhosis.

Typically, heavy drinking needs to be sustained for at least ten years for liver cirrhosis to develop. The period varies according to each individual.

Regular heavy female drinkers are more likely to develop symptoms compared to men who consume the same amount.

Heavy drinkers will eventually develop fatty liver. The liver breaks down alcohol into carbon dioxide and water, causing fatty liver. As soon as excessive drinking stops the symptoms of fatty liver go away. However 20% to 30% of those who continue drinking heavily will develop alcoholic hepatitis, the next stage. Approximately 10% of heavy drinkers will subsequently develop liver cirrhosis – the third stage of alcoholic liver disease.

Males not to exceed three to four units of alcohol consumption per day, and woman should not have more than two to three units daily – to reduce the risk of developing alcohol hepatitis and liver cirrhosis.

Hepatitis
Hepatitis C, a blood borne infection, can damage the liver and eventually lead to liver cirrhosis. Liver cirrhosis can also be caused by hepatitis B and D.

Non-alcoholic steatohepatitis (NASH)
NASH is more likely to occur with people who are obese, diabetes patients, those with high blood lipid (fat) levels, as well as individuals with hypertension (high blood pressure). NASH, in its early stages, begins with the accumulation of too much fat in the liver. The fat causes inflammation and scarring, resulting in possible liver cirrhosis later on.

Autoimmune Hepatitis
The person’s own immune system attacks healthy organs in the body as though they were foreign substances. Sometimes the liver is attacked. Eventually the patient can develop liver cirrhosis.

Some Genetic Conditions

  • Hemochromatosis – Iron accumulates in the liver and other parts of the body.
  • Wilson’s disease – Copper accumulates in the liver and other parts of the body.

Blockage of Bile Ducts
Some conditions and disease, such as cancer of the bile ducts, or cancer of the pancreas can block the bile ducts, increasing the risk of liver cirrhosis.

Budd-Chiari Syndrome
There is thrombosis (blood clots) in the hapatic vein, the blood vessel that carries blood from the liver, leading to liver enlargement and the development of collateral vessels.

Other disease and conditions
Some of the other diseases and conditions that can contribute to liver cirrhosis are:

  • Cystic fibrosis
  • Primary sclerosing cholangitis – hardening and scarring of the bile ducts
  • Galactosemia – inability to process sugars in milk
  • Schistosomiasis – a parasite commonly found in some developing countries
  • Biliary atresia – badly formed bile ducts in babies
  • Glycogen storage disease – problems in the storage and energy release vital for cell function

 

Symptoms of Liver Cirrhosis

A symptom is something the patient feel and reports, while a sign is something other people, including a doctor or a nurse may detect. For example, pain may be a symptom while a rash may be a sign.

Symptoms are not common during the early stages of liver cirrhosis. However, as scar tissue accumulates the liver’s ability to function properly is undermined. The following signs and symptoms may occur:

  • Blood capillaries become visible on the skin on the upper abdomen
  • Fatigue
  • Insomnia
  • Itchy skin
  • Loss of appetite
  • Loss of body weight
  • Nausea
  • Pain or tenderness in the area where the liver is located
  • Red or blotchy palms
  • Weakness

 

The following signs and symptoms may appear as liver cirrhosis progresses:

  • Abdomen fills up with fluid, giving the patient a large tummy (ascites)
  • Accelerated heartbeat
  • Altered personality (as blood toxins build up and affect the brain)
  • Bleeding gums
  • Body and upper arms lose mass
  • Body finds it harder to process alcohol
  • Confusion
  • Dizziness
  • Fluid buildup on ankles, feet and legs (edema)
  • Hair loss
  • Higher susceptibility to bruising
  • Jaundice (yellowing of the skin, whites of the eyes and tongue)
  • Loss of libido (sex drive)
  • Memory problems
  • More frequent fevers (susceptibility to infections)
  • Muscle cramps
  • Nosebleeds
  • Pain on the right shoulder
  • Painting (breathlessness)
  • Stools become black and tarry, or very pale
  • Urine becomes darker
  • Vomiting blood
  • Walking problems (staggering)

 

Diagnosis of Liver Cirrhosis

Liver cirrhosis in its early stages is often diagnosed when the patient is being tested for some other condition or disease because symptoms are not present.

Anybody who has the following symptoms should see their doctor immediately:

  • Fever with shivering
  • Panting (shortness of breath)
  • Vomiting blood
  • Dark stools, or tarry stools (as if covered with tar)
  • Episodes of drowsiness or confusion

A general practitioner, primary care physician will examine the patient and feel around the liver area to determine whether it is enlarged. The patient will be asked about his/her medical history and lifestyle (drinking, etc)

The following tests may also be ordered:
A Blood Test – To measure how well the liver is functioning and determine whether there is any damage. If levels of ALT (Alanine Transaminase) are high the patient may have hepatitis.

Imaging Tests – This may involve an ultrasound, CT (Computerised Tomography) or MRI (Magnetic Resonance Imaging) scan of the liver. Apart from seeing whether the liver is enlarged, the doctor will also be able to detect any scarring.

A Biopsy – A small sample of liver cells are extracted and examined under a microscope. The doctor inserts a fine needle in between the ribs and into the liver. The patient will receive a local aesthetic. The biopsy not only confirms or rules out liver cirrhosis, but also reveal it cause (if it is liver cirrhosis).

Endoscopy – An endoscope, a long, thin tube with a light and video camera at the end goes down the patient’s windpipe (esophagus) and into their stomach. The doctor sees the inside of the stomach on a screen, and looks out for swollen blood vessels (varices); a hallmark sign of liver cirrhosis.

Child-Pugh Score – Also known as the Child-Turcotte-Pugh score, assesses the prognosis (outlook) of chronic liver disease, mainly liver cirrhosis. Originally, it was used to predict mortality during surgery, but is now used to determine prognosis, as well as the required treatment strength, and whether or not the patient needs a liver transplant. It is a combination of numbered points and the letters A, B, C (see below):


 

Treatment of Liver Cirrhosis

If the liver cirrhosis is diagnosed early enough, damage may be minimised by treating its underlying cause.

  • Alcohol Dependency (alcoholism) Treatment – It is important for the patient to stop drinking if their liver cirrhosis was caused by long-term, regular heavy alcohol consumption. In many cases the doctor will recommend a treatment program for alcoholism.
  • Medications – The patient may be prescribed drugs to control liver cell damage caused by hepatitis B or C.

 

Treating Liver Cirrhosis Complications

Ascites or Edema – Ascites (accumulation of fluid in the abdomen) or adema (fluid retention in the legs) can be treated with a low-sodium (salt) diet and water pills. In severe cases the fluid may have to be drained. Sometimes surgery is required.

Pressure In The Portal Vein and Collateral Smaller Veins – Hypertension (high blood pressure) drugs are usually prescribed to control the increasing pressure in the blood vessels around the liver; the aim is to prevent severe bleeding. In some cases a stent may be surgically placed in the portal vein to hold it open. Signs of bleeding can be detected via an endoscopy.

Treatment of Swollen Varices – If the patient vomits blood or passes bloody stools they probably have esophageal varices (in the food pipe). urgent medical attention is required. The following procedures may help:

  • Banding – a small band is placed around the base of the varices to control bleeding. An endoscope goes down the patient’s throat and esophagus during the procedure.
  • Injection Sclerotherapy – After an endoscopy a substance is injected into the varices which triggers a blood clot and scar tissue to form; this helps stem the bleeding.
  • A Sengstaken Tube With a Balloon – The balloon is at the end of the tube. If endoscopy does not stop the bleeding a tube goes down the patient’s throat and into their stomach. The balloon is inflated; this places pressure on the varices and stops the bleeding.
  • TIPSS (Tranjugular Intrahepatic Portosystemic Stent Shunt) – If the above-mentioned therapies do not stem the bleeding, a stent (metal tube) is passed across the liver to join the portal and hepatic veins, creating a new route for the blood to flow through. This reduces pressue – pressure which was causing the varices.
  • Infections – The patient will be given antibiotics, and some other treatments.
  • Screening for liver cancer – Patients with liver cirrhosis have a much higher risk of developing liver cancer. The doctor may recommend regular blood tests and imaging scans.
  • Hepatic Encephalopathy (High Blood Toxin Levels) – Drugs can help treat excessive blood toxin levels. The signs and symptoms need to be explained to the patient so that they know what to look out for.
  • Liver Transplant – If the liver cirrhosis is advanced and there is liver failure (liver does not function) the patient may need a liver transplant.

 

Prevention of Liver Cirrhosis

Alcohol – do not exceed the recommend daily/weekly alcohol limit.

  • Men: Maximum of 21 units per week, or three/four units per day
  • Women: Maximum of 14 units per week, or two/three units per day

Individual who have liver cirrhosis should abstain from alcohol completely. Alcohol accelerates the progression of the disease.

Hepatitis B and C

  • Use a condom when having sex
  • Do not share needles when injecting drugs
  • People at risk of becoming infected with hepatitis B, such as health care workers, social care workers, and police personnel can be vaccinated (there is currently no vaccine for hepatitis C).